View the list of articles:


  • Distorted TCR repertoires define multisystem inflammatory syndrome in children.
    Malik A, Tóth EN, Teng MS, Hurst J, Watt E, Wise L, Kent N, Bartram J, Grandjean L,
    Dominguez-Villar M, Adams S, Cooper N.
    Under review (Preprint)


  • Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation.
    Selck C, Dominguez-Villar M
    Front Immunol

  • Editorial: control of regulatory T cell stability, plasticity and function in health and disease.
    Piconese S, Walker LSK, Dominguez-Villar M
    Front Immunol

  • Oleic acid induces tissue-resident Foxp3 regulatory T cell function.
    Pompura SL, Wagner A, Kitz A, LaPerche J, Yosef N, Dominguez-Villar M, Hafler DA
    J Clin Invest (highlighted in The New England Journal of Medicine)


  • Modulation of regulatory T cell function and stability by co-inhibitory receptors.
    Lucca LE,
    Dominguez-Villar M
    Nat Rev Immunol


  • TLR7 and TLR8 activate distinct pathways during RNA virus infection.
    De Marcken M, Dhaliwal K, Gautron AS,
    Dominguez-Villar M
    Sci Signal

  • TIGIT signalling restores suppressor function of Th1-Tregs.
    Lucca LE, Axisa PP, Singer ER, Nolan EM, Dominguez-Villar M, Hafler DA
    JCI Insight

  • Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.
    Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA.
    J Autoimmun


  • Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.
    Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA
    Nat Immunol

  • Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.
    Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA
    J Autoimmun

  • Interactions between tumor associated macrophages and tumor cells in glioblastoma: unraveling promising targeted therapies.
    Morisse MC, Jouannet S, Dominguez-Villar M, Sanson M, Idbaih A
    Expert Rev Neurother

  • Regulatory T cells in autoimmune diseases.
    Dominguez-Villar M and Hafler DA
    Nat Immunol

  • The PI3K/AKT pathway on regulatory T cell development, function and stability.
    Pompura S, Dominguez-Villar M
    J Leukoc Biol


  • Molecular mechanisms underlying Th1-like Treg generation and function.
    Kitz A, Dominguez-Villar M
    Cel Mol Life Sci

  • Immune modulation by the hepatitis C virus core protein.
    Fernández-Ponce C, Dominguez-Villar M, Muñoz-Miranda JP, Arbulo-Echevarria MM, Litrán R, Aguado E, García-Cozar F
    J Viral Hepat


  • AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.
    Kitz A, de Marcken M, Gautron AS, Mitrovic, M, Hafler DA, Dominguez-Villar M.
    EMBO Rep

  • Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.
    Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC,
    Dominguez-Villar M, Garcia-Cozar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ.
    J Leukoc Biol


  • Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
    Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C
    J Immunol

  • TLR7 induces anergy in human CD4+ T cells.
    Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA.
    Nat Immunol (Recommended at F1000prime and highlighted in Nature Immunology News and Views)


  • Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.
    Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA
    Eur J Immunol

  • Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
    Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA
    J Clin Invest

  • CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells.
    Fernandez-Ponce C, Dominguez-Villar M, Aguado E, Garcia-Cozar F
    PLoS One


  • The TIGIT/CD226 axis regulates human T cell function.
    Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA.
    J Immunol

  • Up-regulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein.
    Dominguez-Villar M, Fernandez-Ponce C, Munoz-Suano A, Gomez E, Rodriguez-Iglesias M, Garcia-Cozar F
    Clin Sci (Lond)

  • The effects of hepatitis C virus core protein on functional responses in the NK cell line YTS.
    Dominguez-Villar M, Garcia-Cozar FJ, Chambers BJ
    Scand J Immunol


  • Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.
    Dominguez-Villar M, Baecher-Allan CM, Hafler DA
    Nat Med (Recommended at F1000Prime and highlighted in Sci Transl Med Editor’s choice)

  • Immunology. An innate role for IL-17.
    Dominguez-Villar M, Hafler DA.

  • CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
    Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA
    J Immunol

  • Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
    Martinez-Florensa M, Garcia-Blesa A, Yelamos J, Munoz-Suano A, Dominguez-Villar M, Valdor R, Alonso A, Garcia-Cozar F, Aparicio P, Malissen B, Aguado E
    J Leukoc Biol

  • Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.
    Konry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML.
    Biosens Bioelectron


  • Concurrent overexpression of serum p53 mutation related with Helicobacter pylori infection.
    Lopez-Saez JB, Gomez-Biondi V, Santamaria-Rodriguez G, Dominguez-Villar M, Amaya-Vidal A, Lorenzo-Penuelas A, Senra-Varela A
    J Exp Clin Cancer Res


  • Chemosensitivity test on brain tumors.
    Gil-Salu JL, Bosco-Lopez J, Dominguez-Villar M, Dominguez-Pascual I, Perez-Requena J, Palomo MJ, Lopez-Escobar M.
    Neurocirurgia (Astur)

  • Metabolic profile of breast cancer in a population of women in southern Spain.
    Lopez-Saez JB, Martinez-Rubio JA, Alvarez MM, Carrera CG, Dominguez Villar M, de Lomas Mier AG, Domenech C, Senra-Varela A.
    Open Clin Cancer J

  • Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.
    Valdor R, Schreiber V, Saenz L, Martinez T, Munoz-Suano A, Dominguez-Villar M, Ramirez P, Parrilla P, Aguado E, Garcia-Cozar F, Yelamos J
    Mol Immunol


  • Hepatitis C virus core protein up-regulates anergy-related genes and a new set of genes, which affects T cell homeostasis.
    Dominguez-Villar M, Munoz-Suano A, Anaya-Baz B, Aguilar S, Novalbos JP, Giron JA, Rodriguez-Iglesias M, Garcia-Cozar F
    J Leukoc Biol

Book Chapters

  • PI3K isoforms and T cell function.
    Zaheer SA, Cameron B,
    Dominguez-Villar M
    Springer book on PI3K isoforms in immunity (In preparation)

  • Regulatory T cells as a therapy for autoimmune diseases.
    Selck C, Dominguez-Villar M.
    Chapter 5 (pages 33-46) of
    Hematopoietic stem cell transplantation and cellular therapies for autoimmune diseases.
    Editor: Richard K Burt, CRC Press, Taylor & Francis Group